|
KMID : 0380620180500050511
|
|
Korean Journal of Food Science and Technology
2018 Volume.50 No. 5 p.511 ~ p.516
|
|
|
Immunomodulatory activities of polysaccharides extracted Cudrania tricuspidata fruits in macrophage
|
|
Cho Eun-Ji
Kim Yi-Eun
Byun Eui-Hong
|
|
|
Abstract
|
|
|
|
Macrophages play a crucial role in the host immune defense system. The current study investigated immunomodulatory activities induced by polysaccharides extracted from Cudrania tricuspidata (CTPS) fruits in murine macrophages and their role in signaling pathways. In macrophages, CTPS predominantly induced nitric oxide (NO), tumor necrosis factor-a, and interleukin-6 production. In addition, CTPS significantly up-regulated expression of the macrophage surface marker (CD80/ 86 and MHC class I/II). These results indicate that polysaccharides extracted from CTPS may potentially play an immunomodulatory role in macrophages via mitogen-activated protein kinases and nuclear factor-B signaling. These findings may be useful in the development of immune enhancing adjuvant materials obtained from natural sources.
|
|
|
KEYWORD
|
|
|
Cudrania tricuspidata fruits polysaccharide, immunomodulatory activity, macrophage, nitric oxide, cytokine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|